Comparative Evaluation of Common Comorbidity Scores and Freiburger Comorbidity Index as Prognostic Variables in a Real Life Multiple Myeloma Population

Autor: Başak Ünver Koluman, Vedat Aslan, Ozge Soyer Kosemehmetoglu, Harika Okutan, Birgül Öneç, Murat Albayrak, Esra Saribacak Can
Rok vydání: 2015
Předmět:
Zdroj: Indian Journal of Hematology and Blood Transfusion. 32:424-430
ISSN: 0974-0449
0971-4502
DOI: 10.1007/s12288-015-0618-y
Popis: albayrak, murat/0000-0003-4025-741X WOS: 000386685400009 PubMed: 27812251 Multiple myeloma (MM) is a disease of the geriatric population with a median age at diagnosis of 69 years but most clinicians consider performance status and comorbidities rather than chronological age in determining prognosis and treatment. The purpose of this study was to assess whether and which comorbidity indices predict survival in a real life population of MM. We calculated Charlson Comorbidity Index (CCI), age combined Charlson index (CCI-age), Hematopoietic cell transplantation-specific comorbidity index (HCT-SCI) and Freiburger comorbidity index (FCI) retrospectively for 66 MM patients and compared their impact on treatment responses and overall survival (OS). Treatment response was significantly worse in groups with high CCI, CCI-age, HCT-SCI scales (p < 0.05), but FCI's effect on treatment response was not significant. However, while no significant relationship was determined between other comorbidity indices with OS, it was related only with FCI-CI (p = 0.006). FCI, developed in this patient group, was the only prognostic index with a significant effect on OS in the evaluation of comorbidities in MM patients with different scores, but its relationship to treatment responses was not significant contrary to other indices. While this small patient group gave us hope regarding the use of FCI in practice, multi-center studies are still required.
Databáze: OpenAIRE
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