Sodium [18F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment
| Autor: | Sabri Sahnoun, Felix M. Mottaghy, Alexandru Florea, Andreas T. J. Vogg, Julius P. Sigl, Jan Bucerius, Agnieszka Morgenroth, Oliver Winz, Leon J. Schurgers |
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| Přispěvatelé: | RS: Carim - B06 Imaging, Beeldvorming, Biochemie, RS: Carim - B02 Vascular aspects thrombosis and Haemostasis |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aortic arch Pathology medicine.medical_specialty 030204 cardiovascular system & hematology vitamin K 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo medicine.artery Sodium fluoride sodium fluoride medicine Von Kossa stain lcsh:QH301-705.5 Aorta medicine.diagnostic_test business.industry Warfarin General Medicine 3. Good health micro-calcification cardiovascular diseases warfarin 030104 developmental biology medicine.anatomical_structure chemistry lcsh:Biology (General) Ventricle Positron emission tomography vascular calcification positron-emission tomography business medicine.drug |
| Zdroj: | Cells Cells, Vol 10, Iss 275, p 275 (2021) Cells, 10(2):275. Multidisciplinary Digital Publishing Institute (MDPI) Cells 10(2), 275 (2021). doi:10.3390/cells10020275 special issue: "Special Issue "Research on Vascular Calcification in Cardiovascular Disease" / Special Issue Editors: Prof. Dr. Leon Schurgers, Guest Editor; Dr. Peter Stenvinkel, Guest Editor" Volume 10 Issue 2 |
| ISSN: | 2073-4409 |
| DOI: | 10.18154/rwth-conv-248190 |
| Popis: | Given the high sensitivity and specificity of sodium [18F]Fluoride (Na[18F]F) for vascular calcifications and positive emerging data of vitamin K on vascular health, the aim of this study is to assess the ability of Na[18F]F to monitor therapy and disease progression in a unitary atherosclerotic mouse model. ApoE&minus /&minus mice were placed on a Western-type diet for 12-weeks and then split into four groups. The early stage atherosclerosis group received a chow diet for an additional 12-weeks, while the advanced atherosclerosis group continued the Western-type diet. The Menaquinone-7 (MK-7) and Warfarin groups received MK-7 or Warfarin supplementation during the additional 12-weeks, respectively. Control wild type mice were fed a chow diet for 24-weeks. All of the mice were scanned with Na[18F]F using a small animal positron emission tomography (PET)/computed tomography (CT). The Warfarin group presented spotty calcifications on the CT in the proximal aorta. All of the spots corresponded to dense mineralisations on the von Kossa staining. After the control, the MK-7 group had the lowest Na[18F]F uptake. The advanced and Warfarin groups presented the highest uptake in the aortic arch and left ventricle. The advanced stage group did not develop spotty calcifications, however Na[18F]F uptake was still observed, suggesting the presence of micro-calcifications. In a newly applied mouse model, developing spotty calcifications on CT exclusively in the proximal aorta, Na[18F]F seems to efficiently monitor plaque progression and the beneficial effects of vitamin K on cardiovascular disease. |
| Databáze: | OpenAIRE |
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