The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function
| Autor: | Sean P. Colgan, Bonny L. Dickinson, Richard S. Pitman, Edward E. S. Nieuwenhuis, Gerburg M. Spiekermann, Richard S. Blumberg, Steven M. Claypool, Xiaoping Zhu, Yvonne D. Van De Wal, Wayne I. Lencer, Nadia Corazza |
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| Rok vydání: | 2001 |
| Předmět: |
CD8 Antigens
T-Lymphocytes CD1 Receptors Antigen T-Cell Genes MHC Class I Human leukocyte antigen Major histocompatibility complex Article Major Histocompatibility Complex Neonatal Fc receptor Antigen Receptors KIR HLA Antigens MHC class I Humans Receptors Immunologic General Dentistry Immunity Mucosal Membrane Glycoproteins biology Histocompatibility Antigens Class I Epithelial Cells General Medicine Molecular biology Histocompatibility Killer Cells Natural biology.protein Chromosomes Human Pair 6 beta 2-Microglobulin CD8 |
| Zdroj: | Acta odontologica Scandinavica. 59(3) |
| ISSN: | 0001-6357 |
| Popis: | The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A, B, and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa beta2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including CD1, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology. |
| Databáze: | OpenAIRE |
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