Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
| Autor: | Muhammad Kashif Malik, Sultan Altayyar, Yasser Sakr, Ali Talag, Ali S. Omrani, Abdullah Abudayah, Mohammed M. Albarrak, Ghaleb A. Almekhlafi, Yasser Mandourah, Tareef Aldaghestani, Mohamed Mustafa, Abid Alwan, Adnan Alghamedi, Sahar Hassan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pediatrics medicine.medical_specialty Middle East respiratory syndrome coronavirus viruses 030106 microbiology Saudi Arabia Epidemic Respiratory failure Critical Care and Intensive Care Medicine medicine.disease_cause law.invention Cohort Studies MERS-CoV 03 medical and health sciences 0302 clinical medicine law medicine Humans 030212 general & internal medicine Aged Retrospective Studies Coronavirus business.industry Research virus diseases Retrospective cohort study Middle Aged medicine.disease Respiration Artificial Intensive care unit Intensive Care Units Middle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome Female Presentation (obstetrics) Coronavirus Infections business Cohort study |
| Zdroj: | Critical Care |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/s13054-016-1303-8 |
| Popis: | Background Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Methods Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples. Results During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11–302.1, P = 0.04). Conclusions MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients. Electronic supplementary material The online version of this article (doi:10.1186/s13054-016-1303-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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