Exosomes Transfer p53 between Cells and Can Suppress Growth and Proliferation of p53-Negative Cells

Autor: Evgeny M. Makarov, E. Yu. Varfolomeeva, R. A. Kovalev, Michael V. Filatov, R. A. Pantina, Vladimir Burdakov
Rok vydání: 2018
Předmět:
Zdroj: Cell and Tissue Biology. 12:20-26
ISSN: 1990-5203
1990-519X
Popis: Exosomes are nanosized vesicles that are secreted by many types of cells. We have found that exosomes secreted by HEK293 and HT-1080 can suppress growth and proliferation of p53-deficient cells. Upon overexpression of exogenous p53-GFP in HEK293 cells, we observed p53 protein in exosomes that were secreted by these cells. We also found endogenous p53 in exosomes that were secreted by HT-1080 cells with a higher level of p53 expression. We were able to detect endogenous p53 protein in exosomes that originated from human plasma and were transferred to p53-deficient cells. Our findings indicate that p53 protein can be transferred between cells and may play an important physiological role.
Databáze: OpenAIRE
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