ICM0301s, New Angiogenesis Inhibitors from Aspergillus sp. F-1491: I. Taxonomy, Fermentation, Isolation and Biological Activities
| Autor: | Kazuyuki Dobashi, Masaaki Ishizuka, Kunio Isshiki, Daishiro Ikeda, Hiroyuki Kumagai, Tetsuya Someno |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Antifungal Agents Angiogenesis medicine.medical_treatment Intraperitoneal injection Basic fibroblast growth factor Angiogenesis Inhibitors Antineoplastic Agents Microbial Sensitivity Tests Naphthalenes Muscle Smooth Vascular Fibrin Umbilical vein Cell Line Rats Sprague-Dawley Mice chemistry.chemical_compound Organ Culture Techniques Cell Line Tumor Drug Discovery medicine Animals Humans Cytotoxicity Aorta Chromatography High Pressure Liquid Pharmacology Mice Inbred ICR Aspergillus biology Chemistry Fungi biology.organism_classification Molecular biology Rats Fermentation biology.protein Epoxy Compounds |
| Zdroj: | The Journal of Antibiotics. 57:97-103 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.57.97 |
| Popis: | In the course of screening program for inhibitors of angiogenesis, novel substances designated as ICM0301A approximately H (1 approximately 8) were isolated from the culture broth of Aspergillus sp. F-1491. ICM0301s inhibited the growth of human umbilical vein endothelial cells (HUVECs) induced by basic fibroblast growth factor (bFGF) with IC50 values of 2.2 approximately 9.3 microg/ml. ICM0301A (1) showed significant anti-angiogenic activity at lower than 10 microg/ml in the angiogenesis model using rat aorta cultured in fibrin gel. ICM0301s showed very low cytotoxicity against various tumor cells. Furthermore, 1CM0301A did not show any toxic symptom in mice by intraperitoneal injection at 100 mg/kg. |
| Databáze: | OpenAIRE |
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