Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat
| Autor: | Michael J. DeVito, Michael F. Hughes, David G. Ross, Brenda C. Edwards, James M. Starr |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Insecticides Time Factors Health Toxicology and Mutagenesis Bifenthrin Adipose tissue Administration Oral 010501 environmental sciences Pharmacology Toxicology 01 natural sciences Biochemistry Risk Assessment 03 medical and health sciences chemistry.chemical_compound Pharmacokinetics Tandem Mass Spectrometry Jugular vein Pyrethrins Animals Rats Long-Evans Tissue Distribution Pyrethroid insecticide Chromatography High Pressure Liquid 0105 earth and related environmental sciences Pyrethroid Brain General Medicine Bioavailability Rats 030104 developmental biology Blood chemistry Adipose Tissue Liver Time course Administration Intravenous |
| DOI: | 10.6084/m9.figshare.1569019 |
| Popis: | 1. Pyrethroids are neurotoxic and parent pyrethroid appears to be toxic entity. This study evaluated the oral disposition and bioavailability of bifenthrin in the adult male Long-Evans rat. 2. In the disposition study, rats were administered bifenthrin (0.3 or 3 mg/kg) by oral gavage and serially sacrificed (0.25 h to 21 days). Blood, liver, brain and adipose tissue were removed. In the bioavailability study, blood was collected serially from jugular vein cannulated rats (0.25 to 24 h) following oral (0.3 or 3 mg/kg) or intravenous (0.3 mg/kg) administration of bifenthrin. Tissues were extracted and analyzed for bifenthrin by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). 3. Bifenthrin concentration in blood and liver peaked 1-2-h postoral administration and were approximately 90 ng/ml (or g) and 1000 ng/ml (or g) for both tissues at 0.3 and 3 mg/kg, respectively. Bifenthrin was rapidly cleared from both blood and liver. Brain concentrations peaked at 4-6 h and were lower than in blood at both doses (12 and 143 ng/g). Bifenthrin in adipose tissue peaked at the collected time points of 8 (157 ng/g) and 24 (1145 ng/g) h for the 0.3 and 3 mg/kg doses, respectively and was retained 21 days postoral administration. Following intravenous administration, the blood bifenthrin concentration decreased bi-exponentially, with a distribution half-life of 0.2 h and an elimination half-life of 8 h. Bifenthrin bioavailability was approximately 30%. These disposition and kinetic bifenthrin data may decrease uncertainties in the risk assessment for this pyrethroid insecticide. |
| Databáze: | OpenAIRE |
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