The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study
| Autor: | Ethem Tankurt, Servet Akar, H Akbaylar Akpinar, Mehmet Tunca, N Hizli, Oded Gonen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Systemic disease Abdominal pain medicine.medical_specialty medicine.medical_treatment Drug Resistance Alpha interferon Familial Mediterranean fever Pilot Projects Blood Sedimentation Gastroenterology Gout Suppressants Leukocyte Count chemistry.chemical_compound Rheumatology Internal medicine medicine Humans Colchicine Pharmacology (medical) Adverse effect Interferon alfa Chemotherapy Platelet Count business.industry Interferon-alpha medicine.disease Familial Mediterranean Fever C-Reactive Protein chemistry Immunology Female medicine.symptom business medicine.drug |
| Zdroj: | Rheumatology. 36:1005-1008 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/36.9.1005 |
| Popis: | About a quarter of familial Mediterranean fever (FMF) patients have recurrent painful attacks of polyserositis despite regular colchicine treatment. There is no known alternative drug for colchicine-resistant cases. We had previously observed a patient with FMF whose painful attacks disappeared during the 6 month period of interferon alpha (IFN) treatment for his chronic hepatitis B. The objective of the present study was to investigate the possible beneficial effect of IFN on these episodes. Twenty-one consecutive attacks in seven adult patients with FMF were treated at early onset with IFN, the dosage being 3-10 million I U s.c. Eighteen of the 21 attacks could be halted in a mean time of 3.05 h, while the intensity of abdominal pain remained very low. Observed side-effects were generally mild and acceptable. IFN may be a useful adjunct for the treatment of colchicine-resistant attacks in FMF patients. |
| Databáze: | OpenAIRE |
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