Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats
| Autor: | Di Dai, Naren Bao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Article Subject medicine.medical_treatment Interleukin-1beta Immunology Intraperitoneal injection Ischemia Renal function Apoptosis Inflammation Pharmacology medicine.disease_cause Neuroprotection Rats Sprague-Dawley In Situ Nick-End Labeling medicine polycyclic compounds Pathology Animals RB1-214 Kidney Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha business.industry Acute kidney injury Cell Biology Acute Kidney Injury medicine.disease Rats Oxidative Stress medicine.anatomical_structure Reperfusion Injury medicine.symptom business Dexmedetomidine Oxidative stress hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | Mediators of Inflammation, Vol 2020 (2020) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympatholytic qualities. The aim of this study was to establish whether DEX also offers protection against ischemia and reperfusion- (I/R-) induced AKI in rats. An intraperitoneal injection of DEX (25 μg/kg) was administered 30 min prior to the induction of I/R. The results indicate that in the I/R rats, DEX played a protective role by reducing the damage to the tubules and maintaining renal function. Furthermore, in response to I/R, the DEX treatment reduced the mRNA expression of TNF-α, IL-1β, IL-6, and MCP-1 in the kidney tissues and the serum levels of TNF-α, IL-1β, IL-6, and MCP-1. DEX also reduced the levels of oxidative stress and apoptosis in the tubular cells. These results indicate that in response to I/R kidney injury, DEX plays a protective role by inhibiting inflammation and tubular cell apoptosis, reducing the production of reactive oxygen species, and promoting renal function. |
| Databáze: | OpenAIRE |
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