Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula
| Autor: | Eero Vasar, R.J. Pasterkamp, Linda J. Richards, Sara Brignani, Ewoud R.E. Schmidt, Sharon M. Kolk, Kersti Lilleväli, Youri Adolfs, Amber Lee Skye Donahoo, Jeroen Demmers, Suzanne Lemstra, Domna Karagogeos, Marina Vidaki |
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| Přispěvatelé: | Biochemistry |
| Rok vydání: | 2014 |
| Předmět: |
Neuroscience(all)
Efferent Mice Neural Pathways Netrin medicine Biological neural network Extracellular Animals Nerve Growth Factors Neurons Afferent Axon Mice Knockout Habenula Chemotactic Factors Cell adhesion molecule Chemotaxis Dopaminergic Neurons Tumor Suppressor Proteins General Neuroscience Dopaminergic Molecular Animal Physiology Lysosome-Associated Membrane Glycoproteins Netrin-1 Axons medicine.anatomical_structure nervous system Synapses Psychology Neuroscience |
| Zdroj: | Neuron, 83(2), 372-387. Cell Press Neuron, 83, 2, pp. 372-87 Neuron, 83, 372-87 Neuron |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2014.05.036 |
| Popis: | SummaryA dominant feature of neural circuitry is the organization of neuronal projections and synapses into specific brain nuclei or laminae. Lamina-specific connectivity is controlled by the selective expression of extracellular guidance and adhesion molecules in the target field. However, how (sub)nucleus-specific connections are established and whether axon-derived cues contribute to subdomain targeting are largely unknown. Here, we demonstrate that the lateral subnucleus of the habenula (lHb) determines its own afferent innervation by sending out efferent projections that express the cell adhesion molecule LAMP to reciprocally collect and guide dopaminergic afferents to the lHb—a phenomenon we term subdomain-mediated axon-axon signaling. This process of reciprocal axon-axon interactions cooperates with lHb-specific chemoattraction mediated by Netrin-1, which controls axon target entry, to ensure specific innervation of the lHb. We propose that cooperation between pretarget reciprocal axon-axon signaling and subdomain-restricted instructive cues provides a highly precise and general mechanism to establish subdomain-specific neural circuitry.Video Abstract |
| Databáze: | OpenAIRE |
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