Hepatitis B vaccination status and vaccine immune response among children in rural Senegal
| Autor: | Aldiouma Diallo, E Ba, Cheikh Sokhna, S Ndiour, Marion Coste, Lauren Perières, Sylvie Boyer, P Halfon |
|---|---|
| Přispěvatelé: | Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen [Fondation Ambroise Paré - Marseille], Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), COMBE, Isabelle, Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.disease_cause
03 medical and health sciences 0302 clinical medicine Immune system [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Immunity [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology 030212 general & internal medicine ComputingMilieux_MISCELLANEOUS [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases Hepatitis B virus [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases business.industry 030503 health policy & services Public Health Environmental and Occupational Health Phlebotomy Virology [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system 3. Good health Vaccination Chronic infection Immunization Hepatitis b vaccination [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 0305 other medical science business [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology |
| Zdroj: | European Journal of Public Health European Journal of Public Health, 2019, 29 (Supplement_4), ⟨10.1093/eurpub/ckz185.592⟩ European Journal of Public Health, Oxford University Press (OUP): Policy B-Oxford Open Option D, 2019, 29 (Supplement_4), ⟨10.1093/eurpub/ckz185.592⟩ |
| ISSN: | 1101-1262 1464-360X |
| Popis: | Background Hepatitis B vaccination during childhood is key to reduce the prevalence of Hepatitis B virus (HBV) infection. In Senegal, a highly endemic country, the three-dose hepatitis B vaccine and the birth dose vaccine were introduced in the Expanded Programme on Immunization (EPI) in 2004 and 2016 respectively. This study aimed to determine chronic HBV infection prevalence, hepatitis B vaccination status and vaccine immunity among children in Senegal. Methods A cross-sectional study including HBV screening was conducted at home among children aged 6 months to 15 years (i.e. born after the introduction of the HBV vaccine in the EPI) in the rural zone of Niakhar. Dried Blood Spot (DBS) samples were collected for the detection of HBsAg, anti-HBc Ab and anti-HBs Ab using chemoluminescence. Vaccination status was assessed using information on vaccination cards. Detectable vaccine immunity was defined with an adjusted DBS threshold of DOI≥0.36 IU/mL (corresponding to 10 IU/mL in venous blood sampling). Results Between October and December 2018, 455 children were enrolled. Preliminary results show that 7/455 (1.5%) had been in contact with HBV (positive anti-HBc Ab) and 5/455 (1.1%) had chronic HBV infection (positive HBsAg). Only 161/455 (35.4%) children had a vaccination card available. Among those, 150/161 (93.2%) received at least 3 doses of hepatitis B vaccine, of which 83/150 (55.3%) had detectable vaccine immunity. The proportion of children with detectable vaccine immunity was significantly higher in children Conclusions Preliminary results suggest a low prevalence of HBV chronic infection among children born after the introduction of HBV vaccination in Senegal. However, detectable vaccine immunity rapidly decreases with age among vaccinated children, signalling a need for further studies on the immune response to HBV vaccination in this context. Key messages HBV chronic infection is low among children born after the introduction of HBV vaccination in Senegal. Further studies on the immune response to HBV vaccination in this context are needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|