Biochemical and cytochemical analyses of BNP-stimulated guanylate cyclase in frog choroid plexus
| Autor: | Daniela Vagnetti, Farnesi Rm, Simonetta Tei, B. Santarella, T. Secca, Carla Roscani |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Swine medicine.drug_class Central nervous system Nerve Tissue Proteins Biology Epithelium Rana Cerebrospinal fluid Ependyma Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Animals Receptor Molecular Biology Microvilli Histocytochemistry General Neuroscience Rana esculenta Epithelial Cells Brain natriuretic peptide Microscopy Electron medicine.anatomical_structure Endocrinology Guanylate Cyclase Choroid Plexus Choroid plexus Neurology (clinical) Developmental Biology |
| Zdroj: | Brain Research. 705:295-301 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(95)01178-1 |
| Popis: | This study shows that in the choroid plexus of Rana esculenta particulate guanylate cyclase (GC) is appreciably stimulated by porcine brain natriuretic peptide (BNP). Ultracytochemical tests for GC show that BNP notably increases the enzymatic reaction product along the apical surfaces of the epithelial cells. It can therefore be hypothesized that the apical zone of the epithelial cells possess receptors which have a particular affinity for BNP produced in the central nervous system and dumped into the cerebrospinal fluid. These results, together with those of a previous study [32], confirm that the choroid plexus is an organ which has receptors for the natriuretic peptides which are involved in the processes of osmoregulation and the control of cerebrospinal fluid production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect