Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery
| Autor: | Nao Ishiko, Corinne A. Lee-Kubli, Nigel A. Calcutt, Kristine Tolentino, Yimin Zou, Maysam Pessian, Edmund R. Hollis |
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| Rok vydání: | 2015 |
| Předmět: |
Spinal
Thalamus Central nervous system General Physics and Astronomy Hindlimb Biology General Biochemistry Genetics and Molecular Biology Article Lesion Ganglia Spinal Neuroplasticity medicine Animals Axon Spinal Cord Injuries Neurons Inbred F344 Multidisciplinary Neuronal Plasticity Proprioception Rehabilitation Neurosciences General Chemistry Anatomy Recovery of Function Rats Inbred F344 Axons Rats Nerve Regeneration Proprioceptive function medicine.anatomical_structure Synapses Neurological Ganglia Female medicine.symptom Neuroscience |
| Zdroj: | Nature communications, vol 6, iss 1 |
| Popis: | Studies show that limited functional recovery can be achieved by plasticity and adaptation of the remaining circuitry in partial injuries in the central nervous system, although the new circuits that arise in these contexts have not been clearly identified or characterized. We show here that synaptic contacts from dorsal root ganglions to a small number of dorsal column neurons, a caudal extension of nucleus gracilis, whose connections to the thalamus are spared in a precise cervical level 1 lesion, underwent remodeling over time. These connections support proprioceptive functional recovery in a conditioning lesion paradigm, as silencing or eliminating the remodelled circuit completely abolishes the recovered proprioceptive function of the hindlimb. Furthermore, we show that blocking repulsive Wnt signalling increases axon plasticity and synaptic connections that drive greater functional recovery. |
| Databáze: | OpenAIRE |
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