Augmented Secretion of Atrial and Brain Natriuretic Peptides During Dynamic Exercise in Patients With Old Myocardial Infarction

Autor: Mareomi Hamada, Kunio Hiwada, Masahito Aburaya, Kazumasa Marumoto
Rok vydání: 1995
Předmět:
Adult
Male
medicine.medical_specialty
Physiology
medicine.drug_class
Rest
Physical Exertion
Myocardial Infarction
Cardiac index
Nerve Tissue Proteins
Ventricular Function
Left
Atrial natriuretic peptide
Internal medicine
Natriuretic Peptide
Brain
Ventricular Pressure
medicine
Natriuretic peptide
Humans
Pulmonary Wedge Pressure
cardiovascular diseases
Myocardial infarction
Radionuclide Imaging
Pulmonary wedge pressure
Aged
Analysis of Variance
Ejection fraction
business.industry
Heart
Stroke Volume
Middle Aged
medicine.disease
Brain natriuretic peptide
Thallium Radioisotopes
Exercise Test
Linear Models
cardiovascular system
Cardiology
Ventricular pressure
Female
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
hormones
hormone substitutes
and hormone antagonists
circulatory and respiratory physiology
Zdroj: Japanese Circulation Journal. 59:715-724
ISSN: 1347-4839
0047-1828
Popis: To assess the role of atrial and brain natriuretic peptides (ANP, BNP) in maintaining cardiac performance at rest and during exercise in patients with cardiac dysfunction, we measured plasma levels of ANP and BNP during 201Tl dynamic exercise testing in 32 patients with angiographically proven old myocardial infarction (OMI) and 35 normal control subjects (CS). Plasma levels of ANP and BNP at rest were significantly higher in patients with OMI than in CS (ANP, 42.6 +/- 19.3 vs 19.4 +/- 2.4 pg/ml, p < 0.01; BNP, 53.4 +/- 32.5 vs 2.8 +/- 0.8 pg/ml, p < 0.01, respectively). Correlations were found between plasma levels of these peptides and left ventricular ejection fraction (LVEF), cardiac index (CI), pulmonary capillary wedge pressure (PCWP) and left ventricular end-diastolic pressure (LVEDP) in patients with OMI. In addition, a strong positive correlation was found between plasma levels of these peptides and the severity score obtained from 201TI myocardial scintigraphy. During exercise, both ANP and BNP significantly increased in patients with OMI. However, in CS, although ANP increased, BNP remained unchanged. The changes in plasma levels of ANP or BNP from at rest to peak exercise correlated with LVEF, CI, PCWP, LVEDP and the severity score in patients with OMI. These findings indicate that ANP and BNP play an important role in maintaining cardiac performance at rest and during exercise in patients with cardiac dysfunction.
Databáze: OpenAIRE
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