In vitro evaluation of the cyto- and genotoxicity of titanium and titanium-based alloy Ti-6Al-4V used in the manufacture of screw type dental implants - preliminary study
| Autor: | Mădălina Malița, Radu Costea, Corina Marilena Cristache, Teodora Marcu, Irina Adriana Beuran, Constantin Florin Drăgan, Pharmacy, Bucharest, Romania, Nicoleta Constantin, Liliana Burlibașa, Augustin Mihai, Iuliana Babiuc, Mihai Burlibașa, Gabriela Tănase, Mihaela Chirilă, Viorel Stefan Perieanu, Madalina Violeta Perieanu, Raluca Costea |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Romanian Journal of Medical Practice, Vol 16, Iss 2, Pp 188-195 (2021) |
| ISSN: | 2069-6108 1842-8258 |
| Popis: | Introduction. Titanium and the alloys that contain this element became in the last decade of the twentieth century almost irreplaceable materials in many biomedical fields, including dentistry. Purpose. The purpose of this study is to test and evaluate the cyto- and genotoxicity of Ti4 and Ti-6Al-4V, to obtain biomaterials with antimicrobial properties, compatible with the human body. Material and method. Ti4 and Ti-4Al-6V in powder form were analyzed using cell proliferation analysis and micronucleus test. Two concentrations of 1.5 mg/ml and 3 mg/ml were tested for each type of sample. Results and discussions. For both materials tested in the two concentrations, the presence of micronuclei was observed, but within normal limits. Conclusions. Although the variations are within normal limits, it should be noted that for Ti-6Al-4V the incidence was higher at both concentrations than in the case of Ti4. |
| Databáze: | OpenAIRE |
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