Factors Associated With the Benefits of Concurrent Administration of Intratympanic Steroid Injection With Oral Steroids in Patients With Acute Acoustic Trauma
| Autor: | Young-Soo Chang, Kanghyun Bang, Gang-Gyu Lee, Nayeon Choi, Jong Sei Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Steroid injection Hearing loss Prednisolone Administration Oral Time-to-Treatment 03 medical and health sciences Young Adult 0302 clinical medicine Hearing Medicine Humans Acoustic trauma In patient Young adult 030223 otorhinolaryngology Glucocorticoids Retrospective Studies Injection Intratympanic medicine.diagnostic_test Multivariable linear regression business.industry Retrospective cohort study Sensory Systems Military Personnel Treatment Outcome Otorhinolaryngology Hearing Loss Noise-Induced 030220 oncology & carcinogenesis Anesthesia Neurology (clinical) Audiometry medicine.symptom business |
| Zdroj: | Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 39(5) |
| ISSN: | 1537-4505 |
| Popis: | Objective To analyze the factors associated with the benefits of concurrent administration of intratympanic steroid injection (ITSI) and oral steroids in patients with acute acoustic trauma (AAT) incurred during military training. Study design Retrospective analysis. Patients Nineteen patients eligible under the criteria established concerning treatment for AAT were retrospectively reviewed in this study. Interventions ITSI treatments were administered simultaneously alongside oral prednisolone. Main outcome measures Patients were categorized into two groups depending on the time elapsed between exposure to the noise and treatment initiation: 1) "Early Treatment initiation," defined as the treatment being initiated between 3 and 7 days; and 2) "Delayed treatment initiation," defined as the treatment being initiated in >7 days. Pure-tone air conduction threshold audiometry, to record the pure-tone average (PTA) at 2, 4, and 8 kHz, was conducted upon each patient's initial visit, and 1 month after starting treatment. The degree of hearing gain (hearing gain [dB] = [initial PTA] - [final PTA]) was calculated and used as the metric for determining the treatment's outcome. The initial PTA and treatment onset were adopted as possible associated factors. Results The mean ages of each group were 22.00 ± 2.12 years and 22.83 ± 2.64 years, respectively (p = 0.28). The initial PTAs were 46.41 ± 12.73 dB and 47.22 ± 14.74 dB, respectively (p = 1.00).In the multivariable linear regression analysis, the initial PTA and the treatment initiation showed a significant association (R = 0.37). The unstandardized regression coefficient of the initial PTA was 0.37 (p = 0.04). Patients with early treatment initiation showed significant improvement in the degree of hearing gain compared with delayed treatment initiation (unstandardized regression coefficient = 12.63, p = 0.01). Conclusions We demonstrated the importance of early treatment onset for maximizing the benefits of concurrent administration of ITSI with oral steroids in patients with AAT suffered during military training. Further evaluation is needed to confirm the factors associated with the efficacy of concurrent ITSI with oral steroids. |
| Databáze: | OpenAIRE |
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