Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors
| Autor: | Babu L. Tekwani, Antonello Mai, Larry A. Walker, Silvio Massa, Sergio Valente, Ilaria Cerbara |
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| Rok vydání: | 2004 |
| Předmět: |
Plasmodium falciparum
Leishmania donovani Antiprotozoal Agents Hydroxamic Acids Chromatin remodeling Genus: Leishmania Antimalarials parasitic diseases medicine Animals Pharmacology (medical) Pyrroles Antimalarial Agent Enzyme Inhibitors Letter to the Editor Pharmacology biology biology.organism_classification medicine.disease Virology Histone Deacetylase Inhibitors Infectious Diseases Histone Biochemistry biology.protein Histone deacetylase Malaria |
| Zdroj: | Antimicrobial agents and chemotherapy. 48(4) |
| ISSN: | 0066-4804 |
| Popis: | Members of the genus Leishmania are parasitic protozoans that infect about two million people per annum (5), and they are emerging as serious opportunistic infective agents in human immunodeficiency virus-infected patients (4). Malaria parasites are responsible for 1.5 to 2.7 million deaths annually, primarily in Africa (10). The effort to find new antimalarial agents is still a high priority given the increasing malaria emergency largely due to multidrug-resistant Plasmodium falciparum strains. The histones of P. falciparum have recently been proposed as targets for drug treatment of blood stage parasites (6). They also play an important role in chromatin remodeling in trypanosomatids, which include Leishmania species and trypanosomes (3). |
| Databáze: | OpenAIRE |
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