Electrostatic gating of ion transport in carbon nanotube porins: A modeling study
| Autor: | Aleksandr Noy, Mark A. Reed, Zhongwu Li, Shari Yosinski, Yun Chiao Yao, Alice J. Gillen |
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| Rok vydání: | 2021 |
| Předmět: |
Nanotube
Ion Transport Materials science 010304 chemical physics Nanotubes Carbon Static Electricity Porins General Physics and Astronomy Nanotechnology Gating Carbon nanotube Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences 0104 chemical sciences law.invention Membrane law 0103 physical sciences Electric potential Physical and Theoretical Chemistry Lipid bilayer Ion transporter Voltage |
| Zdroj: | The Journal of Chemical Physics. 154:204704 |
| ISSN: | 1089-7690 0021-9606 |
| DOI: | 10.1063/5.0049550 |
| Popis: | Carbon nanotube porins (CNTPs) are biomimetic membrane channels that demonstrate excellent biocompatibility and unique water and ion transport properties. Gating transport in CNTPs with external voltage could increase control over ion flow and selectivity. Herein, we used continuum modeling to probe the parameters that enable and further affect CNTP gating efficiency, including the size and composition of the supporting lipid membrane, slip flow in the carbon nanotube, and the intrinsic electronic properties of the nanotube. Our results show that the optimal gated CNTP device consists of a semiconducting CNTP inserted into a small membrane patch containing an internally conductive layer. Moreover, we demonstrate that the ionic transport modulated by gate voltages is controlled by the charge distribution along the CNTP under the external gate electric potential. The theoretical understanding developed in this study offers valuable guidance for the design of gated CNTP devices for nanofluidic studies, novel biomimetic membranes, and cellular interfaces in the future. |
| Databáze: | OpenAIRE |
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