Reflected rather than forward wave pressures account for brachial pressure-independent relations between aortic pressure and end-organ changes in an African community
| Autor: | Hendrik L. Booysen, Pinhas Sareli, Aletta M.E. Millen, Andrew R. Raymond, Muzi J. Maseko, Angela J. Woodiwiss, Moekanyi J. Sibiya, Gavin R. Norton, Olebogeng H.I. Majane, Elena Libhaber |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Mean arterial pressure Brachial Artery Physiology Heart Ventricles Diastole Renal function Black People Pulse Wave Analysis Carotid Intima-Media Thickness Internal medicine Internal Medicine Medicine Humans Arterial Pressure cardiovascular diseases Aortic Pulse Pressure Pulse wave velocity Aorta business.industry Confounding Blood Pressure Determination Organ Size Middle Aged Surgery Blood pressure cardiovascular system Cardiology Aortic pressure Female Cardiology and Cardiovascular Medicine business Glomerular Filtration Rate |
| Zdroj: | Journal of hypertension. 33(10) |
| ISSN: | 1473-5598 |
| Popis: | AIMS To determine whether brachial blood pressure (BP)-independent relations between aortic pressure and cardiovascular damage are better explained by reflected (backward) (Pb) or forward (Pf) wave pressure effects. METHODS In 1174 participants from a community of African ancestry, we assessed central aortic pulse pressure (PPc), Pb, and Pf (radial applanation tonometry, SphygmoCor) as well as left ventricular mass index (LVMI) (n = 786), aortic pulse wave velocity (PWV) (n = 1019), carotid intima-media thickness (IMT) (n = 578), transmitral early-to-late left ventricular diastolic velocity (E/A) (n = 779) and estimated glomerular filtration rate (eGFR) (n = 1174). RESULTS Independent of mean arterial pressure and confounders, PPc, and both Pb and Pf were associated with end-organ measures or damage (P |
| Databáze: | OpenAIRE |
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