Vasohibin-1 expression as a biomarker of aggressive nature in ductal adenocarcinoma of the prostate: a retrospective cohort study at two centres in Japan
| Autor: | Mototsugu Oya, Tokuhiro Kimura, Hiroaki Kobayashi, Takeo Kosaka, Shuji Mikami, Michio Kosugi, Yasufumi Sato, Hiroshi Hongo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Urology CD34 Acinar adenocarcinoma Cell Cycle Proteins Adenocarcinoma Gastroenterology Surgical pathology Japan Prostate Internal medicine medicine Humans Stage (cooking) Retrospective Studies urological tumours Prostatectomy business.industry Cancer Endothelial Cells Prostatic Neoplasms Retrospective cohort study General Medicine medicine.disease digestive system diseases medicine.anatomical_structure Medicine business Biomarkers surgical pathology prostate disease |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 11 (2021) |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesVasohibin-1 (VASH1) is an endogenous angiogenesis regulator expressed in activated vascular endothelial cells. We previously reported that high VASH1 expression is a predictor of progression in acinar adenocarcinoma of the prostate. In this study, we evaluated the characteristics of ductal adenocarcinoma of the prostate by comparing the level of VASH1 expression between ductal and acinar adenocarcinoma specimens.Design and settingA retrospective cohort study at two centres in Japan.ParticipantsAmong the 1495 patients who underwent radical prostatectomy or transurethral resection for the past 15 years, a total of 14 patients diagnosed with ductal adenocarcinoma and 20 patients diagnosed with acinar adenocarcinoma with a Gleason score of 4+4 were included.InterventionsWe immunohistochemically examined the CD34 expression as the microvessel density (MVD) and activated endothelial cells as the VASH1 density (vessels per mm2).Primary and secondary outcome measuresThe primary outcome was the association of MVD and VASH1 density between ductal and acinar adenocarcinoma, and the secondary outcome was their oncological outcomes.ResultsNine patients (64.3%) with ductal adenocarcinoma were diagnosed at an advanced clinical stage, and five patients (35.7%) died from cancer during a median follow-up of 56.0 months. The VASH1 densities (mean±SD) in ductal and acinar adenocarcinoma were 45.1±18.5 vs 16.1±21.0 (pConclusionsDuctal adenocarcinoma was more aggressive and had higher VASH1 expression than acinar adenocarcinoma, although MVD was equivalent. These results indicate that VASH1 expression may serve as a novel biomarker for the aggressive nature of ductal adenocarcinoma. |
| Databáze: | OpenAIRE |
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