Pharmaceutical Society of Japan
| Autor: | Toshihide Maki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Desorption electrospray ionization Matrix-assisted laser desorption electrospray ionization Materials science Photocleavable molecule Small molecule analysis Lasers Analytical chemistry Pharmaceutical Science Laser desorption ionization mass spectrometry General Medicine Mass spectrometry Biochemistry Sample preparation in mass spectrometry Soft laser desorption Atmospheric-pressure laser ionization Surface-enhanced laser desorption/ionization Molecular Weight Chemical physics Labeling Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Matrix-assisted laser desorption/ionization mass spectrometry Quantitative analysis Ambient ionization |
| Zdroj: | Biological and Pharmaceutical Bulletin. 35(9):1413-1416 |
| ISSN: | 0918-6158 |
| Popis: | Recent advances in quantitative approaches to laser desorption/ionization mass spectrometry (LDI-MS) are selectively reviewed. Numerous efforts have been made to use matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and related techniques for rapid screening and/or monitoring of biological events. Among the various mass ionization spectrometric analysis techniques, MALDI-MS has exceptional potential for high-throughput analysis. Although quantitative analysis with MALDI-MS is challenging, the expansion of its utility is inevitable. It is notable that practical improvement of MALDI-MS can be achieved by preparation of an uniform matrix using binary matrix systems. Broad applications have been established with a self-assembled monolayer for MALDI-MS, referred to as SAMDI-MS. The method could be an essential tool not only for rapid screening but also as a sensitive probe for surface sciences. Complementary to these approaches, labeling of molecules for LDI-MS is introduced as potential tool for the selective detection of specific target molecules. Biological and Pharmaceutical Bulletin, 35(9), pp.1413-1416; 2012 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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