A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio
| Autor: | Ji-Feng Feng, Sheng Chen, Qiang Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Lymphocyte Gastroenterology 03 medical and health sciences 0302 clinical medicine cancer-specific survival c-reactive protein Thoracic Oncology Internal medicine Medicine biology business.industry Proportional hazards model C-reactive protein fungi Albumin Cancer Retrospective cohort study medicine.disease esophageal squamous cell carcinoma neutrophil lymphocyte ratio 030104 developmental biology medicine.anatomical_structure Oncology Cardiothoracic surgery 030220 oncology & carcinogenesis biology.protein prognosis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Qiang Zhao 1, 2 , Sheng Chen 1, 2 and Ji-Feng Feng 1, 2 1 Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, P.R.China 2 Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, P.R. China Correspondence to: Ji-Feng Feng, email: Fengjf@zjcc.org.cn , Fengjif@163.com Keywords: esophageal squamous cell carcinoma, c-reactive protein, neutrophil lymphocyte ratio, cancer-specific survival, prognosis Received: July 10, 2017 Accepted: September 23, 2017 Published: October 20, 2017 ABSTRACT Background: We initially proposed a novel inflammation-based prognostic index, named neutrophil lymphocyte ratio/albumin ratio (NLR/Alb), for predicting the postoperative survival in esophageal squamous cell carcinoma (ESCC). Materials and methods: A retrospective study of 329 cases with resectable ESCC was included. The optimal cut-off values were evaluated by X-tile program. The 5-year cancer-specific survival (CSS) was calculated by Kaplan–Meier method. Cox regression analyses were performed to evaluate the prognostic factors. Results: The optimal cut-off value was 0.1 for NLR/Alb according to the X-tile program. There was a significantly better 5-year CSS in patients with NLR/Alb ≤ 0.1 than patients with NLR/Alb > 0.1 (39.1% vs. 11.0%, P < 0.001). According to multivariate analyses, NLR/Alb ( P = 0.001) was an independent prognostic factor. Conclusions: The NLR/Alb is a novel and usefull predictive factor in patients with ESCC. |
| Databáze: | OpenAIRE |
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