Persistent reduction of pancreatic Beta-cell mass after a limited period of protein-energy malnutrition in the young rat
| Autor: | A. H. Schnell Landström, Ingemar Swenne, C. J. Crace, L. A. H. Borg |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Protein–energy malnutrition Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Protein-Energy Malnutrition Rats Sprague-Dawley Islets of Langerhans Low-protein diet Diabetes mellitus Internal medicine Internal Medicine medicine Animals Pancreatic islets Insulin Age Factors Kwashiorkor Organ Size medicine.disease Rats Microscopy Electron Malnutrition Glucose Endocrinology medicine.anatomical_structure Female Dietary Proteins Pancreas |
| Zdroj: | Diabetologia. 35:939-945 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00401422 |
| Popis: | Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary protein-energy malnutrition in young rats causes a persisting impairment of insulin secretion. The present study investigates whether this secretory deficiency is accompanied by structural alterations of the endocrine pancreas. Three-week-old rats were weaned onto semi-synthetic diets containing either 15% or 5% protein and these diets were maintained for 3 weeks. From 6 weeks of age all rats were fed a commercial chow containing 18% protein. The endocrine pancreas was investigated by light and electron microscopic morphometry at 3, 6 and 12 weeks of age. In rats not subjected to protein-energy malnutrition there was a progressive increase, with age, of total pancreatic Beta-cell weight and individual Beta-cell size. In 6-week-old rats fed the low protein diet total pancreatic Beta-cell weight and individual Beta-cell size were diminished. In 12-week-old rats previously fed the low protein diet total Beta-cell weight remained lower compared to control rats. It is concluded that protein-energy malnutrition early in life may result in a diminished reserve for insulin production. This may predispose to glucose intolerance or even diabetes in situations with an increased insulin demand. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink