The effect of erythrocyte membranes from diabetic and hypercholesterolemic individuals on human carbonic anhydrase II activity
| Autor: | Akın Bodur, Ahmet Alver, Selim Demir, Yunus Emre Yandı, Ahmet Mentese, Ayşe Şentürk, Sermet Yildirmis |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Physiology Carbonic anhydrase II Type 2 diabetes Biology Carbonic Anhydrase II 03 medical and health sciences human carbonic anhydrase II Physiology (medical) Internal medicine medicine Membrane fluidity Humans Erythrocyte membrane chemistry.chemical_classification hypercholesterolemia Healthy subjects General Medicine medicine.disease In vitro 030104 developmental biology Endocrinology Membrane Enzyme Diabetes Mellitus Type 2 chemistry Case-Control Studies Female Activity regulation type 2 diabetes |
| Zdroj: | Archives of Physiology and Biochemistry. 122:14-18 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | Erythrocyte membranes regulate many enzyme activities, including carbonic anhydrase II (CA II). Membrane fluidity is associated with alterations in protein function and protein-protein interactions. Objective: The purpose of this study was to show the human CA II (hCA II) activity regulation by human erythrocyte membranes from diabetic and hypercholesterolemic subjects. Materials and methods: Erythrocyte membranes were obtained from diabetic, hypercholesterolemic, and healthy subjects. hCA II activity was measured using the electrometric method. Results: hCA II activity was increased in vitro by membranes from both diabetic and hypercholesterolemic patients, with hypercholesterolemic membranes exhibiting a greater increase. Conclusion: Changes in membrane composition may affect the erythrocyte membranes capacity to increase in vitro hCA II activity. © 2015 Taylor and Francis. |
| Databáze: | OpenAIRE |
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