Alteration of human serum albumin binding properties induced by modifications: A review
| Autor: | M. Maciążek-Jurczyk, Jadwiga Pożycka, Agnieszka Szkudlarek, Anna Sułkowska, Mariola Chudzik |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Glycosylation Time Factors Serum protein Serum Albumin Human Analytical Chemistry 03 medical and health sciences Glycation medicine Humans Instrumentation Spectroscopy Physiological function Binding Sites Chemistry Binding properties Albumin Human serum albumin Atomic and Molecular Physics and Optics Biomarker (cell) 030104 developmental biology Biochemistry Ageing Oxidation-Reduction medicine.drug Protein Binding |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 188 |
| ISSN: | 1873-3557 |
| Popis: | Albumin, a major transporting protein in the blood, is the main target of modification that affects the binding of drugs to Sudlow's site I and II. These modification of serum protein moderates its physiological function, and works as a biomarker of some diseases. The main goal of the paper was to explain the possible alteration of human serum albumin binding properties induced by modifications such as glycation, oxidation and ageing, their origin, methods of evaluation and positive and negative meaning described by significant researchers. |
| Databáze: | OpenAIRE |
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