A weakly antimalarial biflavanone from Rhus retinorrhoea
| Autor: | Farouk S. El-Feraly, Daneel Ferreira, Jaber S. Mossa, Mahmoud A. ElSohly, Abdel-Rahim S. Ibrahim, Samir A. Ross, Mohamed S. Ahmed, Ahmed M. Galal |
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| Rok vydání: | 2001 |
| Předmět: |
clone (Java method)
Staphylococcus aureus Rhus Plasmodium falciparum Microbial Sensitivity Tests Plant Science Horticulture medicine.disease_cause Biochemistry Mycobacterium Microbiology Antimalarials chemistry.chemical_compound Anti-Infective Agents parasitic diseases medicine Animals Biflavonoids Candida albicans Molecular Biology Candida Flavonoids Molecular Structure biology Spectrum Analysis Mycobacterium smegmatis Biological activity General Medicine Eriodictyol biology.organism_classification Antimicrobial Anti-Bacterial Agents chemistry |
| Zdroj: | Phytochemistry. 58:599-602 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/s0031-9422(01)00244-8 |
| Popis: | The biflavanone (2S,2"S)-7,7"-di-O-methyltetrahydroamentoflavone and five known flavonoids, 7-O-methylnaringenin, 7,3'-O-dimethylquercetin, 7-O-methylapigenin, 7-O-methylluteolin, and eriodictyol were isolated from the leaves of Rhus retinorrhoea Steud, Ex Olive. The biflavanone exhibited moderate antimalarial activity with IC50 0.98 microg/ml against Plasmodium falciparum (W2 Clone) and weak activity against P. falciparum (D6 Clone) with IC50 2.8 microg/ml. Nevertheless, it did not display any cytotoxicity. 7-O-Methylnaringenin showed weak antimicrobial activity against Candida albicans, C. krusei, Staphylococcus aureus, Mycobacterium smegmatis, M. intracellulare, and M. xenopi with MIC approximately 100 microg/ml. Characterization of each compound was based on spectral analysis and comparison with reported data. |
| Databáze: | OpenAIRE |
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