Biphenotypic Acute Leukemia with t(15;17)
| Autor: | Mariano Scolnik, Maria M.E. de Bracco, Maria Teresa Cuello, M. Giunta, P. Negri Aranguren, María Fernanda Palacios, Susana Acevedo, J. Sanjurjo |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Neoplasm Residual Acute Biphenotypic Leukemia Trisomy T-15 Biology Immunophenotyping Biphenotypic Acute Leukemia hemic and lymphatic diseases medicine Humans Child In Situ Hybridization Fluorescence Chromosome Aberrations Gene Rearrangement Chromosomes Human Pair 15 Leukemia Reverse Transcriptase Polymerase Chain Reaction Hematology Flow Cytometry medicine.disease Lymphoma Oncology Acute Disease Chromosome Inversion Immunology Female Chromosomes Human Pair 17 Chromosomes Human Pair 8 |
| Zdroj: | Leukemia & Lymphoma. 46:607-610 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428190412331272730 |
| Popis: | Biphenotypic acute leukemias (BAL) represent 5% of all acute leukemias. The most frequent cytogenetic abnormalities described are Philadelphia chromosome and 11q23 involvement. Here we report a BAL case, with blasts showing lymphoblast morphology and positivity for myeloperoxidase (in 6% of the blast cells). Immunophenotype revealed the compromise of myeloid and B-lymphoid lineages. Cytogenetic analysis showed the t(15;17) and 8 trisomy. PML/RARa rearrangement was detected by fluorescent in situ hybridization (FISH) on interphase nuclei while PML/RARa fusion transcript was detected in the bone marrow and peripheral blood by molecular biology studies (RT-PCR). This report describes a BAL case with an unfrequent cytogenetic abnormality, and highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis and treatment in BAL patients. |
| Databáze: | OpenAIRE |
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