Use of markers of dyslipidemia to identify overweight youth with insulin resistance
| Autor: | Fida Bacha, Janine E. Janosky, Tamara S. Hannon, SoJung Lee, Silva A. Arslanian |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Abdominal Fat Overweight Sensitivity and Specificity Absorptiometry Photon Insulin resistance Internal medicine Internal Medicine medicine Humans Insulin Triglycerides Dyslipidemias Retrospective Studies Adiponectin business.industry nutritional and metabolic diseases medicine.disease Obesity Endocrinology Adipose Tissue ROC Curve Pediatrics Perinatology and Child Health Glucose Clamp Technique Female Insulin Resistance Metabolic syndrome medicine.symptom Lipoproteins HDL Tomography X-Ray Computed business Body mass index Biomarkers Dyslipidemia |
| Zdroj: | Pediatric Diabetes. 7:260-266 |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/j.1399-5448.2006.00199.x |
| Popis: | Context: Markers to identify overweight youth with insulin resistance are of clinical importance. Objective: To determine if markers of dyslipidemia could identify overweight adolescents with insulin resistance. Setting, Participants, and Study Design: We retrospectively examined the association between markers of dyslipidemia and insulin resistance in 35 overweight [body mass index (BMI) of ≥95th percentile], white adolescents [mean age 13.5 ± (SD) 1.6 yr] who had participated in hyperinsulinemic–euglycemic clamp studies to evaluate insulin action. Total body fat was measured by dual-energy X-ray absorptiometry and abdominal fat with computed tomography. Using receiver-operating curves, cut-points for triglyceride (TG)/high-density lipoprotein (HDL) and TG level to identify overweight individuals in the lowest tertile for insulin sensitivity were determined. Main Outcome Measure: Difference in the values for insulin sensitivity among the groups. Results: Of the markers examined (TG, TG/HDL, adiponectin, measures of adiposity and fasting insulin), fasting insulin was the strongest correlate of insulin sensitivity (r = 0.87, p < 0.001). Youth with TG/HDL level ≥3 had lower insulin sensitivity (50% lower median values, p < 0.01) and higher visceral fat (p < 0.05) despite BMI comparable to that of youth with TG/HDL level |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|