Renal COX-2, Cytokines and 20-HETE: Tubular and Vascular Mechanisms
Autor: | John C. McGiff, Mairead A. Carroll, Nicholas R. Ferreri, John Quilley |
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Rok vydání: | 2004 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Nephron Kidney Internal medicine Hydroxyeicosatetraenoic Acids Drug Discovery Renin–angiotensin system Diabetes Mellitus Animals Humans Medicine Glucocorticoids Pharmacology Ion Transport biology Tumor Necrosis Factor-alpha business.industry Microcirculation Membrane Proteins Angiotensin II Isoenzymes Kidney Tubules Endocrinology Cytokine medicine.anatomical_structure Eicosanoid Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases biology.protein Cytokines Cyclooxygenase Signal transduction business Receptors Calcium-Sensing |
Zdroj: | Current Pharmaceutical Design. 10:613-626 |
ISSN: | 1381-6128 |
DOI: | 10.2174/1381612043453063 |
Popis: | Our initial studies on renal cyclooxygenase (COX)-2 expression and activity addressed the critical role of angiotensin II (Ang II) in increasing tumor necrosis factor alpha (TNF) that eventuated in expression of COX-2 in the medullary thick ascending limb (mTAL) of the nephron. COX-2 supplanted the dominant oxygenase, the cytochrome P450 (CYP) enzyme, omega-hydroxylase, that synthesized 20-hydroxyeicosatetraenoic acid (20-HETE). These findings served as the basis for additional studies on: 1) the role of glucocorticoids in regulating COX-2 expression and activity in the mTAL; and 2) the utilization of the same signaling pathways in response to stimulation of the mTAL calcium receptor (CaR). These studies of mTAL COX-2 expression which are addressed in the first part of this chapter are followed by explorations of the expression of COX-2 in preglomerular microvessels (PGMV) and the relationship of COX-2 to 20-HETE, the principal eicosanoid of PGMV. The third and last component of this chapter explores the signaling events, focusing on COX-2, which are set in motion by diabetes. |
Databáze: | OpenAIRE |
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