Selenoprotein P in Patients on Home Parenteral Nutrition
| Autor: | T. Rannem, Wenhu Huang, Michael Staun, Björn Åkesson, M Persson-Moschos |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty GPX3 030309 nutrition & dietetics Arbitrary unit Radioimmunoassay Nutritional Status Medicine (miscellaneous) chemistry.chemical_element 03 medical and health sciences 0302 clinical medicine Reference Values Selenoprotein P Internal medicine medicine Humans Selenoproteins Aged chemistry.chemical_classification Glutathione Peroxidase 0303 health sciences Nutrition and Dietetics integumentary system biology Glutathione peroxidase Proteins Middle Aged Endocrinology chemistry biology.protein Female 030211 gastroenterology & hepatology Selenoprotein Parenteral Nutrition Home Selenium Peroxidase |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 20:287-291 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/0148607196020004287 |
| Popis: | BACKGROUND The purpose of this study was to evaluate the use of selenoprotein P as an indicator of selenium status in patients receiving home parenteral nutrition. METHODS Adult patients (n = 38) who had been on parenteral nutrition with no addition of selenium for 3 to 216 months were included in the study. Plasma samples were analyzed for selenium, selenoprotein P, and extracellular glutathione peroxidase (eGSHPx) using fluorimetry and newly developed radioimmunoassays. RESULTS The mean plasma (+/- SD) eGSHPx and selenoprotein P in the patients were 1.9 +/- 1.2 mg/L and 0.7 +/- 0.4 arbitrary units, respectively, which corresponds to about 50% of the concentration measured in the plasma of the reference subjects (4.0 +/- 1.0 mg/L and 1.50 +/- 0.17 arbitrary units). The mean plasma selenium concentration was 0.5 +/- 0.4 mumol/L, which was approximately half of the concentration measured in the healthy subjects (1.1 +/- 0.2 mumol/L). Thirty-four (89%) and 20 (53%) patients, respectively, had selenoprotein P and eGSHPx values lower than mean - 2 SD of the reference material. The lowest values observed for selenoprotein P and eGSHPx were 3% and 2% of the reference mean. Selenoprotein P levels correlated significantly to eGSHPx (p = 0.88, p < .0001) and plasma selenium (p = 0.91, p < .0001). CONCLUSIONS The positive correlations between selenoprotein P and eGSHPX and plasma selenium indicates that selenoprotein P may be used as a marker of selenium status in selenium-depleted patients. |
| Databáze: | OpenAIRE |
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