Confusing preclinical (predictive) drug screens with animal ‘models’ of psychiatric disorders, or ‘disorder-like’ behaviour, is undermining confidence in behavioural neuroscience
| Autor: | SC Stanford |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Psychotropic Drugs medicine.medical_specialty Evidence-Based Medicine Psychotherapist Drug screens Mental Disorders Interpretation (philosophy) MEDLINE Behavioral neuroscience 030227 psychiatry Test (assessment) Disease Models Animal 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine medicine Animals Humans Pharmacology (medical) Psychology Psychiatry 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Psychopharmacology. 31:641-643 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Preclinical (predictive) screens for psychotropic drugs are often used, incorrectly, as animal ‘models’ of psychiatric disorders, or to study ‘disorder-like’ behaviours. This misunderstanding is contributing to poor translation and is undermining confidence in behavioural neuroscience. In this editorial, I discuss some of the reasons why the interpretation of results from many of these procedures is dubious because the criteria for validity of the test, as a model of the disorder, have been ignored. Arising from this, I propose that the description of any abnormal behaviour of rodents as a ‘model’ of a psychiatric disorder, or even ‘disorder-like’, without evidence-based justification, should be regarded as unacceptable in this journal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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