A novel voxel-based method to estimate cortical sulci width and its application to compare patients with Alzheimer's disease to controls

Autor: Maria Julieta Mateos, Jorge A. Marquez-Flores, Alfonso Gastelum Strozzi, Fernando A. Barrios, Sarael Alcauter, Ernesto Bribiesca
Rok vydání: 2019
Předmět:
Male
Wilcoxon signed-rank test
Cognitive Neuroscience
Brain morphometry
computer.software_genre
Resonance (particle physics)
050105 experimental psychology
Imaging phantom
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Voxel
Alzheimer Disease
medicine
Image Processing
Computer-Assisted
Humans
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Mathematics
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
business.industry
05 social sciences
Magnetic resonance imaging
Pattern recognition
Sulcus
Magnetic Resonance Imaging
Maxima and minima
medicine.anatomical_structure
Neurology
Euclidean distance transform
Female
Artificial intelligence
Sulcal width
business
Alzheimer’s disease
computer
030217 neurology & neurosurgery
Algorithms
Zdroj: NeuroImage, Vol 207, Iss, Pp 116343-(2020)
ISSN: 1095-9572
Popis: A voxel-based method for measuring sulcal width was developed, validated and applied to a database. This method (EDT-based LM) employs the 3D Euclidean Distance Transform (EDT) of the pial surface and a Local Maxima labeling algorithm. A computational phantom was designed to test method performance; results revealed the method’s inaccuracy δ, to range between 0.1 and 0.5 voxels, for a width that varied between 1 and 7 voxels. Two morphological descriptors were computed to characterize each defined sulcus: mean sulcal width (MSW) and mean absolute deviation (MAD). The former is the average width for all available width measurements within the sulcus, and the latter is the deviation of these measurements. The EDT-based LM method was applied to the Minimal Interval Resonance Imaging in the Alzheimer’s Disease (MIRIAD) database, for a set of high-resolution Magnetic Resonance (MR) images of 66 subjects: 43 patients with Alzheimer Disease (AD) and 23 control subjects. AD causes significant gray matter loss; hence, some sulci were expected to broaden. Methodological results concurred with this hypothesis. After a Wilcoxon test, MSW was grater in the case of all sulci pertaining to AD patients, (p
Databáze: OpenAIRE
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