Photo‐Controlled Reversible Microtubule Assembly Mediated by Paclitaxel‐Modified Cyclodextrin
| Autor: | Kui Xiao, Qilin Yu, Yu Liu, Ni-Yuan Zhang, Ying-Ming Zhang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin 010405 organic chemistry technology industry and agriculture Supramolecular chemistry General Medicine macromolecular substances General Chemistry Protein aggregation 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Supramolecular assembly chemistry.chemical_compound Photochromism Molecular recognition Paclitaxel chemistry Microtubule Biophysics |
| Zdroj: | Angewandte Chemie International Edition. 57:8649-8653 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201804620 |
| Popis: | The design and construction of multi-stimuli-responsive supramolecular nanoassemblies that can mimic and regulate the fundamental biological processes have become a focus of interest in supramolecular chemistry. In this work, a perfect combination has been achieved between naturally occurring microtubules and artificially macrocyclic receptors. The self-assembling morphology of microtubules can be photo-tuned by the host-guest interaction of paclitaxel-modified β-cyclodextrin (PTX-CD) and photochromic arylazopyrazole (PTX-AAP). Moreover, the supramolecularly aggregated microtubules in a cellular environment can induce a pronounced cell morphological change and cell death. This supramolecular approach based on the secondary PTX-AAP⊂PTX-CD complexation provides us a facile method to reversibly control the intertubular aggregation behaviors of microtubules, which may bring new perspectives in the treatment of diseases related to improper protein aggregation. |
| Databáze: | OpenAIRE |
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