Risk of Meningioma in European Patients Treated With Growth Hormone in Childhood: Results From the SAGhE Cohort

Autor: Anders Tidblad, Muriel Thomas, Lars Sävendahl, Christa E. Flück, Dominique Beckers, Peter E. Clayton, Aysha J. Khan, Joël Coste, Stefano Cianfarani, Annalisa Deodati, Jean-Claude Carel, Roland Pfäffle, Sally Tollerfield, Gladys R J Zandwijken, Emmanuel Ecosse, Grit Sommer, Anita C. S. Hokken-Koelega, Gary Butler, Claudia E. Kuehni, Anthony J. Swerdlow, Rosie Cooke, Wieland Kiess
Přispěvatelé: Pediatrics
Rok vydání: 2019
Předmět:
Male
Pediatrics
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
0302 clinical medicine
Endocrinology
Neoplasms
Meningeal Neoplasms
Registries
Child
Growth Disorders
Cumulative dose
Adolescent
Adult
Child
Preschool
Cranial Irradiation
Europe
Female
Follow-Up Studies
Human Growth Hormone
Humans
Incidence
Infant
Infant
Newborn
Meningioma
Neoplasms
Second Primary
Recombinant Proteins
Risk Assessment
Young Adult
Incidence (epidemiology)
Settore MED/38
3. Good health
Growth
Growth Hormone
and Growth Factors
Second Primary
030220 oncology & carcinogenesis
Cohort
Cohort study
medicine.medical_specialty
030209 endocrinology & metabolism
Context (language use)
610 Medicine & health
Malignancy
03 medical and health sciences
360 Social problems & social services
Internal medicine
medicine
Preschool
Clinical Research Articles
business.industry
Biochemistry (medical)
Cancer
medicine.disease
Newborn
business
Zdroj: Journal of Clinical Endocrinology and Metabolism, 104(3), 658-664. Endocrine Society
Clayton, P, Khan, A & et al. 2018, ' Risk of meningioma in European patients treated with growth hormone in childhood: results from the SAGhE cohort ', The Journal of Clinical Endocrinology and Metabolism . https://doi.org/10.1210/jc.2018-01133
Swerdlow, Anthony J; Cooke, Rosie; Beckers, Dominique; Butler, Gary; Carel, Jean-Claude; Cianfarani, Stefano; Clayton, Peter; Coste, Joël; Deodati, Annalisa; Ecosse, Emmanuel; Hokken-Koelega, Anita C S; Khan, Aysha J; Kiess, Wieland; Kuehni, Claudia E; Flück Pandey, Christa Emma; Pfaffle, Roland; Sävendahl, Lars; Sommer, Grit; Thomas, Muriel; Tidblad, Anders; ... (2019). Risk of meningioma in European patients treated with growth hormone in childhood: results from the SAGhE cohort. Journal of clinical endocrinology and metabolism, 104(3), pp. 658-664. Endocrine Society 10.1210/jc.2018-01133
The Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
Popis: Context There has been concern that GH treatment of children might increase meningioma risk. Results of published studies have been inconsistent and limited. Objective To examine meningioma risks in relation to GH treatment. Design Cohort study with follow-up via cancer registries and other registers. Setting Population-based. Patients A cohort of 10,403 patients treated in childhood with recombinant GH in five European countries since this treatment was first used in 1984. Expected rates from national cancer registration statistics. Main Outcome Measures Risk of meningioma incidence. Results During follow-up, 38 meningiomas occurred. Meningioma risk was greatly raised in the cohort overall [standardized incidence ratio (SIR) = 75.4; 95% CI: 54.9 to 103.6], as a consequence of high risk in subjects who had received radiotherapy for underlying malignancy (SIR = 658.4; 95% CI: 460.4 to 941.7). Risk was not significantly raised in patients who did not receive radiotherapy. Risk in radiotherapy-treated patients was not significantly related to mean daily dose of GH, duration of GH treatment, or cumulative dose of GH. Conclusions Our data add to evidence of very high risk of meningioma in patients treated in childhood with GH after cranial radiotherapy, but suggest that GH may not affect radiotherapy-related risk, and that there is no material raised risk of meningioma in GH-treated patients who did not receive radiotherapy.
In a five-country cohort of 10,403 patients treated with recombinant growth hormone, meningioma risk was greatly raised in relation to radiotherapy, but not apparently related to growth hormone.
Databáze: OpenAIRE
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