Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models

Autor:	Di Chen, Hui-fang Zhang, Tian-yi Yuan, Shu-chan Sun, Ran-ran Wang, Shou-bao Wang, Lian-hua Fang, Yang Lyu, Guan-hua Du
Rok vydání:	2021
Předmět:	Pharmacology Monocrotaline Hypertension Pulmonary Rodentia General Medicine Pulmonary Artery Vascular Remodeling Isoflavones Rats Disease Models Animal Mice Phosphatidylinositol 3-Kinases Animals Pharmacology (medical) Hypoxia
Zdroj:	Acta pharmacologica Sinica. 43(9)
ISSN:	1745-7254
Popis:	Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive increase in pulmonary vascular resistance. One of the initial pathogenic factors of PH is pulmonary arterial remodeling under various stimuli. Current marketed drugs against PH mainly relieve symptoms without significant improvement in overall prognosis. Discovering and developing new therapeutic drugs that interfere with vascular remodeling is in urgent need. Puerarin is an isoflavone compound extracted from the root of Kudzu vine, which is widely used in the treatment of cardiovascular diseases. In the present study, we evaluated the efficacy of puerarin in the treatment of experimental PH. PH was induced in rats by a single injection of MCT (50 mg/kg, sc), and in mice by exposure to hypoxia (10% O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666c25bfb27d201cdb25d7342ea8e4b8 https://pubmed.ncbi.nlm.nih.gov/35190697 Zobrazit plný text záznamu Full text from SpringerLink