Neuronal Dysfunction in Patients with Closed Head Injury Evaluated by In Vivo 1H Magnetic Resonance Spectroscopy
| Autor: | Joon-Ki Kang, Tae-Suk Suh, Kyung-Sub Shinn, Kyu-Ho Choi, Park Ck, Bo-Young Choe |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Metabolite Creatine Gastroenterology Choline White matter chemistry.chemical_compound Reference Values In vivo Head Injuries Closed Internal medicine medicine Humans Glasgow Coma Scale Radiology Nuclear Medicine and imaging Cerebral Cortex Aspartic Acid business.industry Glasgow Outcome Scale General Medicine Nuclear magnetic resonance spectroscopy Prognosis medicine.disease medicine.anatomical_structure chemistry Nerve Degeneration Closed head injury Energy Metabolism business Algorithms |
| Zdroj: | Investigative Radiology. 30:502-506 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-199508000-00008 |
| Popis: | RATIONALE AND OBJECTIVES With the use of localized, water-suppressed in vivo 1H magnetic resonance spectroscopy (MRS), the proton metabolic alterations of white matter in patients with closed head injury (CHI) and healthy controls are evaluated, and metabolic alterations with Glasgow Outcome Scale (GOS) scores are compared. METHODS Patients with CHI (n = 10) and healthy control subjects (n = 10) underwent MRS examinations using a stimulated-echo acquisition mode pulse sequence that provided 2 x 2 x 2 cm3 volume of interest in the left frontoparietal white matter. Proton metabolite ratios relative to creatine were obtained using a Marquart algorithm. RESULTS The specific feature in patients with CHI was significant decrease of N-acetylaspartate (NAA)/creatine ratio compared with normal controls. No clear correlation of other metabolite ratios such as choline/creatine and inositols creatine was established. The level of NAA/creatine ratio was significantly correlated with GOS. CONCLUSIONS Results of this preliminary study suggest that the reduction of NAA/creatine ratio may indicate neuronal loss in patients with CHI. The NAA/creatine ratio may serve as a metabolic criterion to predict the GOS of patients with CHI. Thus, in vivo 1H MRS may be a useful modality in the clinical evaluation of patients with CHI based on the proton metabolite concentrations of cerebral white matter. |
| Databáze: | OpenAIRE |
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