Chronic gingivitis in a new BTK mutation
| Autor: | Anthony Liu, Ralph Nanan, David McDonald, Lan-Phuong Dao-Ung |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Lymphocyte Immunoglobulins CD38 Immunoglobulin D Immunophenotyping immune system diseases hemic and lymphatic diseases Agammaglobulinaemia Tyrosine Kinase medicine Humans Point Mutation Bruton's tyrosine kinase CD20 biology Hematology General Medicine Protein-Tyrosine Kinases Flow Cytometry Gingivitis medicine.anatomical_structure Immunoglobulin M Child Preschool Chronic Disease Immunology biology.protein CD5 Antibody |
| Zdroj: | European Journal of Haematology. 76:171-175 |
| ISSN: | 1600-0609 0902-4441 |
| Popis: | A 5-yr-old Caucasian boy with a new mutation in Bruton's tyrosine kinase (BTK) is described. Full sequencing of the BTK gene revealed a point mutation in exon 17 resulting in an amino acid change from tryptophan to serine at location 581 of the tyrosine kinase domain. Clinically the child presented with chronic gingivitis and had no prior history of bacterial infections. Whereas serum immunoglobulin M (IgM) levels were undetectable, IgG levels were in the low normal range. The gingivitis completely resolved after intravenous immunoglobulin therapy. Lymphocyte phenotyping revealed 0.05% B cells in his peripheral blood, which were IgG(-), IgM(+), IgD(+), CD38(+), CD20(+), CD27(-). However, 40% of the B cells also expressed CD5. This subpopulation of B cells has not previously been described in X-linked agammaglobulinaemia (XLA) patients. We suggest that the occurrence of CD5(+) B cells could correlate with a late onset and mild clinical presentations of XLA. |
| Databáze: | OpenAIRE |
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