ORAL GIANT CELL GRANULOMAS: An Enzyme Histochemical and Ultrastructural Study
| Autor: | T. Arwill, Hans Peter Philipsen, G. Heyden, Ole Fejerskov, Lis Andersen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cytoplasm
Stromal cell Biopsy Acid Phosphatase Cell Glucosephosphate Dehydrogenase Cytoplasmic Granules Aminopeptidase Leucyl Aminopeptidase Glutamate Dehydrogenase Granuloma Giant Cell medicine Humans Dihydrolipoamide Dehydrogenase Adenosine Triphosphatases Cell Nucleus Phagocytes biology Histocytochemistry Glutamate dehydrogenase Acid phosphatase Granulation tissue General Medicine Molecular biology Microscopy Electron medicine.anatomical_structure Biochemistry Giant cell Gingival Diseases biology.protein Ultrastructure |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Section A Pathology. :617-629 |
| ISSN: | 0365-4184 |
| Popis: | Oral giant cell granulomas (8 peripheral and 4 central) have been studied histochemically for NADH2-diaphorase, NADPH 2-diaphorase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase, adenosine triphosphatase, leucine aminopeptidase, and acid phosphatase activity. No differences in cellular enzyme activity are found between the peripheral and the central variety. The giant cells are positive for all the enzymes studied, except adenosine triphosphatase, whereas the pericytes of the vascular granulation tissue are positive for all the enzymes tested. 8 peripheral and 2 central oral giant cell granulomas have been studied electron microscopically. The ultrastructure of the two varieties is similar, both showing two different types of giant cells. Clusters of stromal cells, probably pericytes, are often found, lying in intimate relation with a distance of 150–140 A between their cell membranes. Though no membrane fusions have been clearly demonstrated the histochemical activities of the giant cells and the pericytes lend support to the assumption, that the pericytes are precursors to the giant cells. |
| Databáze: | OpenAIRE |
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