Changes in canine C-reactive protein levels following orthopaedic surgery: a prospective study
| Autor: | Noriyuki Hayakawa, Yasuji Harada, Yasushi Hara, Takuya Yogo, Nobuo Kanno, Shuji Suzuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Brief Communication 0403 veterinary science Sepsis Clinical study Postoperative complications Visceral disease Dogs Surgical site medicine Orthopaedic procedures Animals Orthopedic Procedures Postoperative Period Prospective Studies Prospective cohort study Inflammation lcsh:Veterinary medicine General Veterinary biology business.industry Canine inflammatory biomarker C-reactive protein 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine medicine.disease 040201 dairy & animal science C-Reactive Protein Anesthesia Orthopedic surgery biology.protein lcsh:SF600-1100 Female business Biomarkers Blood sampling |
| Zdroj: | Acta Veterinaria Scandinavica Acta Veterinaria Scandinavica, Vol 61, Iss 1, Pp 1-6 (2019) |
| ISSN: | 1751-0147 0044-605X |
| Popis: | C-reactive protein (CRP) is a powerful biomarker for inflammation, infection and sepsis. However, no reports have investigated canine CRP (c-CRP) concentration changes after orthopaedic procedures. If c-CRP changes were better characterized, it may be possible to identify postoperative complications more quickly. The purpose of this study was to clarify the characteristic changes in serum c-CRP after orthopaedic surgery in dogs. Blood samples were collected from 98 dogs on Day 0 (preoperatively), and then on Days 1, 4, 7, 10 and 13 postoperatively. Day 1 blood sampling was performed 12–24 h postoperatively. We classified the dogs into four groups based on changes in c-CRP pre- to postoperatively. Group 1 dogs showed a peak c-CRP concentration on Day 1, followed by decreases of ≥ 1 mg/dL. Group 2 dogs showed changes in c-CRP concentration by Day 4 that were within ± 1 mg/dL compared with Day 1. Dogs in Group 3 showed a peak c-CRP concentration on Day 4, followed by decreases of ≥ 1 mg/dL. Group 4 dogs showed an initial decrease in c-CRP, then an increase of ≥ 1 mg/dL. Group 1 was the largest group, with 63 dogs. c-CRP on Days 0, 1, 4, 7, 10 and 13 was 0.83 ± 1.03 mg/dL, 8.10 ± 3.15 mg/dL, 3.76 ± 1.94 mg/dL, 1.63 ± 0.92 mg/dL, 0.96 ± 0.70 mg/dL and 0.68 ± 0.51 mg/dL, respectively. Serum c-CRP concentration on Day 1 was significantly higher than at every other timepoint (P |
| Databáze: | OpenAIRE |
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