Inhibition of valine utilization by cyclobutaneglycine
| Autor: | Thomas H. Porter, Sherrel C. Smith, William Shive |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Biophysics Glycine Basic hydrolysis Biological Transport Valine biology.organism_classification Biochemistry Amino acid Kinetics chemistry Escherichia Protein Biosynthesis Transfer RNA Escherichia coli Molecular Biology Inhibitory effect Cyclobutanes |
| Zdroj: | Archives of biochemistry and biophysics. 179(1) |
| ISSN: | 0003-9861 |
| Popis: | dl -Cyclobutaneglycine formed by basic hydrolysis of 5-cyclobutylhydantoin prevents the growth of Escherichia coil W in an inorganic salts-glucose medium. This inhibitory effect of the amino acid analog is reversed in a competitive manner over a wide range of concentrations specifically by l -valine. Studies with valyl-tRNA synthetase indicate that cyclobutaneglycine not only prevents the formation of valyl-tRNA but also is transferred to tRNA val . The cellular uptake as well as incorporation into protein of valine is inhibited by cyclobutaneglycine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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