Magnetically Addressable Hydrogels: Towards 3D Printed Spatiotemporally Resolved Thermal Dissipation and Drug Release
| Autor: | Patricia Monks (7898207) |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Magnetics
Inorganic materials (incl. nanomaterials) Chemical Characterisation of Materials FOS: Chemical sciences Printing Three-Dimensional 30304 Physical Chemistry of Materials Hydrogels Physical Chemistry of Materials 30301 Chemical Characterisation of Materials Macromolecular materials Physical properties of materials Structure and dynamics of materials |
| DOI: | 10.25419/rcsi.19719073 |
| Popis: | Multifunctional nanocomposites which exhibit well-defined physical properties are emerging as components for advanced responsive systems, e.g., in soft robotics or drug delivery. Magnetic nanoparticles embedded in these materials (e.g., hydrogels) are attractive due to their resemblance to the extra-cellular matrix (ECM) for cell support and ability to be manipulated in situ by external magnetic fields. The ability to control the distribution of the nanoparticles has the potential to encode spatiotemporally controlled responses, either directly thermal or to trigger a drug response to manipulate cell response. Controlling this distribution at a high-resolution with spatial resolution This thesis attempts to contribute knowledge to the development of platforms and analysis for high-resolution magnetic nanoparticle hydrogel gradients. In the first instance, a 3D printing platform is developed of for an extrusion-based approach for manipulating spatial distribution of heat via magnetic hydrogels (Magnetic Nanoflower/PluronicPF127 Hydrogel) in well-defined printed features. Following on, an in-depth study of the thermal response of these gels is described where rules for heat-induction in bulk hydrogels and the heat-dependence on particle concentration, gel volume, and gel exposed surface area are established. High-concentration, high-resolution prints were shown to provide an acceptable thermal response (> 10 °C). Sufficient heat was generated to trigger a dye release potentially modelling future drug release work. This work also explores the contribution of Néel and Brownian relaxation in gels when choosing a magnetic nanoparticle candidate and touches on an alternative route to spatial patterning via curing a gel and immobilising the nanoparticles in an external magnetic field. Finally, using observations gleaned from the work undertaken above, a secondary school experiment was derived to determine the magnetic response of nanoparticles and demonstrate their unique properties to second level students. Overall, the approach developed here is demonstrated to have potential unobserved control over combined spatial and temporal induction of heat, the applications of which are in developing responsive scaffolds, remodelling, and cargo release for applications in regenerative medicine. |
| Databáze: | OpenAIRE |
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