Diabetes may increase risk for oral cancer through the insulin receptor substrate-1 and focal adhesion kinase pathway
| Autor: | Lambros Goutzanis, E. Patsouris, Ismini Donta, Kavantzas N, Eleftherios Vairaktaris, Panagiotis Skandalakis, Yahya Açil, Emeka Nkenke, Spyridoula Derka, Despoina Perrea, Christos Yapijakis, N. Stavrianeas, Peter Kessler, Stavros Vassiliou |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment medicine.disease_cause Diabetes Mellitus Experimental Rats Sprague-Dawley Focal adhesion Internal medicine Diabetes mellitus Image Processing Computer-Assisted medicine Animals Neoplasm Invasiveness Cell adhesion biology business.industry Insulin Cancer Phosphoproteins medicine.disease Rats IRS1 Insulin receptor Cell Transformation Neoplastic Endocrinology Oncology Focal Adhesion Protein-Tyrosine Kinases Disease Progression Insulin Receptor Substrate Proteins biology.protein Female Mouth Neoplasms Disease Susceptibility Oral Surgery Carcinogenesis business Signal Transduction |
| Zdroj: | Oral Oncology. 43:165-173 |
| ISSN: | 1368-8375 |
| Popis: | In light of recent epidemiological studies that associate diabetes mellitus with increased risk for oral cancer, we investigated in diabetic (type I) and normal rats with induced oral squamous cell carcinoma whether the molecular basis for that putative association involves insulin receptor substrate-1 (IRS-1) and focal adhesion kinase (FAK). Fourteen diabetic and 12 normal rats developed cancer after 4-nitroquinoline-N-oxide treatment, while six diabetic and six normal animals were used as controls. Oral sections were studied using monoclonal antibodies against IRS-1 and FAK proteins. Expression of IRS-1 was significantly higher in diabetic than normal rats, but it decreased in diabetic animals with tumor, especially in more advanced stages. FAK expression was significantly higher in rats with cancer in comparison to the ones without it, regardless the diabetes status. These data suggest that the IRS-1/FAK pathway is altered by diabetes resulting in reduced cell adhesion and possibly increasing risk for oral cancer. |
| Databáze: | OpenAIRE |
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