Mechanical properties and antibiotic release characteristics of poly(methyl methacrylate)-based bone cement formulated with mesoporous silica nanoparticles
| Autor: | Shoucang Shen, Reginald B. H. Tan, Wai Kiong Ng, Wilson Wang, Poddar Kingshuk, Kumaran Letchmanan, Zhilong Shi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Materials science 0206 medical engineering Biomedical Engineering 02 engineering and technology Biomaterials chemistry.chemical_compound Materials Testing Polymethyl Methacrylate Methyl methacrylate Composite material Cement Flexural modulus Bone Cements technology industry and agriculture Mesoporous silica Silicon Dioxide equipment and supplies 021001 nanoscience & nanotechnology Bone cement 020601 biomedical engineering Poly(methyl methacrylate) Anti-Bacterial Agents Drug Liberation Compressive strength chemistry Mechanics of Materials visual_art Drug delivery visual_art.visual_art_medium Nanoparticles 0210 nano-technology |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 72:163-170 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2017.05.003 |
| Popis: | The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15 wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging. In addition, the MSN-functionalized bone cements are able to increase the drug release of gentamicin (GTMC) significantly as compared with commercially available antibiotic-loaded bone cements. It can be attributed to the loaded nano-sized MSNs with uniform pore channels which build up an effective nano-network path enable the diffusion and extended release of GTMC. The combination of excellent mechanical properties and sustainable drug delivery efficiency demonstrates the potential applicability of MSN-functionalized PMMA bone cements for orthopedic surgery to prevent post-surgery infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect