Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran
| Autor: | Mohammad Shaterpour, Novin Nikbakhsh, Ali Barzegar, Ramin Ataee, Seyedeh Habibeh Mirmajidi |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Epidemiology Biology Adenocarcinoma Iran Real-Time Polymerase Chain Reaction Stomach Neoplasms Internal medicine Gene expression medicine Biomarkers Tumor Humans Oncogene Stomach Public Health Environmental and Occupational Health Case-control study Cancer Esophageal cancer medicine.disease Prognosis Gene Expression Regulation Neoplastic medicine.anatomical_structure Real-time polymerase chain reaction Proto-Oncogene Proteins c-bcl-2 Gastric Mucosa Case-Control Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(14) |
| ISSN: | 2476-762X |
| Popis: | BACKGROUND Gastric cancer accounts for about 8% of the total cancer cases and 10% of total cancer deaths worldwide. It is the second lethal cancer after esophageal cancer and is considered the fourth most common cancer in north and northwest Iran. The bcl2 family has a key role in the regulation of apoptosis and change in its expression can contribute to cancer. This study initially scheduled to determine the expression of bcl2 gene in tissue samples of adenocarcinoma cancer patients. MATERIALS AND METHODS A total of 10 samples of gastric adenocarcinoma and 10 of normal tissues from Sari hospital were selected and after DNA extraction from tissues, bcl2 gene expression assayed by real-time PCR. RESULTS Our results demonstrated higher expression of the bcl2 gene in control compared with cancer and marginal cancer tissues. CONCLUSIONS On one hand BCL2 plays an important role as an oncogene to inhibit apoptosis; on the other hand, it can initiate cell cycle arrest at G0 stage. Our observed association between its expression and patient survival is quite conflicting and may be tissue-specific. The data suggest expression both tumoural and non-tumoral(marginal) groups have lowered expression than controls (P>0.05). Due to the low number of samples we could not examine the relationship with clinicopathological features. However, bcl-2 expression may be important for prognostic outcome or a useful target for therapeutic intervention. |
| Databáze: | OpenAIRE |
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