Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Autor:	Eiichi Kodama, Hiroaki Ohno, Rei Tokiwa, Yoji Hata, Kazumi Kajiwara, Kentaro Watanabe, Shinya Oishi, Michinori Tanaka, Hiroko Tsutsumi, Masao Matsuoka, Kazuki Izumi, Nobutaka Fujii
Rok vydání:	2009
Předmět:	Stereochemistry Anti-HIV Agents Recombinant Fusion Proteins Clinical Biochemistry Molecular Sequence Data Pharmaceutical Science Peptide Cleavage (embryo) Biochemistry Chemical synthesis law.invention chemistry.chemical_compound law HIV Fusion Inhibitors Drug Discovery Peptide synthesis Humans Amino Acid Sequence Cysteine Molecular Biology chemistry.chemical_classification Anti hiv Organic Chemistry In vitro chemistry Recombinant DNA Lactam Molecular Medicine Peptides
Zdroj:	Bioorganicmedicinal chemistry. 17(21)
ISSN:	1464-3391
Popis:	Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6662c4577839ef7ed92cbffe1e373e42 https://pubmed.ncbi.nlm.nih.gov/19811922 Zobrazit plný text záznamu Full Text from ScienceDirect