Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens
| Autor: | Hrvoje Mazija, Andreja Prevendar Crnić, Estella Prukner-Radovčić, Jelena Pompe-Gotal, William L. Ragland, Darko Sakar |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Aniline Hydroxylase Quinolones Biology Injections Intramuscular Anti-Infective Agents Internal medicine Marek Disease medicine Enrofloxacin Animals Herpesviridae chemistry.chemical_classification Marek's disease General Veterinary Broiler Viral Vaccines Marek's disease vaccine turkey herpesvirus enrofloxacin hepatic microsomal enzymes broiler chickens Ethylmorphine biology.organism_classification Vaccination Endocrinology Enzyme Liver chemistry Microsomes Liver Microsome Chickens Fluoroquinolones medicine.drug |
| Zdroj: | Acta Veterinaria Hungarica. 52:211-217 |
| ISSN: | 1588-2705 0236-6290 |
| DOI: | 10.1556/avet.52.2004.2.9 |
| Popis: | Chickens were vaccinated against Marek's disease intramuscularly at one day of age. Enrofloxacin was givenad libitumin the drinking water at concentrations of 50, 100 and 250 mg/L from 8 days to 13 days of age when the animals were killed and the activities of cytochrome P-450 enzymes in the liver were measured. Vaccinated non-treated chickens served as a positive control. A negative control group was neither vaccinated nor treated. Vaccination decreased the activity of aniline hydroxylase and ethylmorphine N-demethylase in the positive control group. Subsequent application of enrofloxacin in the lowest concentration (50 mg/L) decreased, while that given at the highest level (250 mg/L) significantly increased the activity of the same microsomal enzymes. Relative liver weights and concentrations of proteins in 9000 ×gsupernatant were not affected by vaccination or treatment. |
| Databáze: | OpenAIRE |
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