Delayed Haematological recovery after autologous stem cell transplantation is associated with favourable outcome in acute myeloid leukaemia
| Autor: | Kurt Leibundgut, Dana Wetzel, Beatrice U. Mueller, Gabriela M. Baerlocher, Thomas Pabst, Behrouz Mansouri Taleghani, Katja Seipel |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty CD34 Transplantation Autologous Gastroenterology 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation hemic and lymphatic diseases Internal medicine medicine Humans Platelet In patient Retrospective Studies business.industry Hematopoietic Stem Cell Transplantation Cytogenetics Hematology Prognosis Survival Analysis 3. Good health Leukemia Myeloid Acute Treatment Outcome 030220 oncology & carcinogenesis Immunology Absolute neutrophil count Female Myeloid leukaemia Stem cell business Nucleophosmin 030215 immunology |
| Zdroj: | British journal of haematology |
| ISSN: | 0007-1048 |
| Popis: | Autologous stem cell transplantation (ASCT) is applied to consolidate first remission in patients with acute myeloid leukaemia (AML). However, outcome after ASCT widely varies among AML patients. We analyzed the prognostic significance of haematological recovery for neutrophils [absolute neutrophil count (ANC) >1·0 × 10(9) /l] and platelets (platelet count >20·0 × 10(9) /l), stratifying at day 20 after ASCT in 88 consecutive and homogeneously treated AML patients in first remission. We observed that patients with delayed recovery had better overall survival (OS; ANC: P < 0·0001 and platelets: P = 0·0062) and time to progression (TTP; ANC: P = 0·0003 and platelets: P = 0·0125). Delayed recovery was an independent marker for better OS and TTP in a multivariate analysis including age, gender, number of transfused CD34+ cells, cytogenetics, FLT3-internal tandem duplication and NPM1 mutation. Our results suggest that delayed neutrophil and platelet recovery is associated with longer OS and TTP in AML patients consolidated with ASCT in first remission. |
| Databáze: | OpenAIRE |
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