Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation
| Autor: | Urska Vrhovsek, Mattia Gasperotti, Elisa Colombo, Marco Fumagalli, Emma De Fabiani, Stefano Piazza, Mario Dell'Agli, Enrico Sangiovanni, Fulvio Mattivi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Anti-Inflammatory Agents Inflammation Biology Transfection Strawberry Fragaria Procianidine 03 medical and health sciences chemistry.chemical_compound Ellagitannins Cell Line Tumor Biological property medicine Humans Secretion Interleukin 8 Settore CHIM/10 - CHIMICA DEGLI ALIMENTI Promoter Regions Genetic Procyanidin B1 Procyanidins Ellagitannini Infiammazione gastrica Pharmacology Plants Medicinal 030109 nutrition & dietetics IL-8 Dose-Response Relationship Drug Plant Extracts Tumor Necrosis Factor-alpha Gastric inflammation Interleukin-8 Cell model NF-kappa B Epithelial Cells Casuarictin In vitro Biochemistry chemistry Gastric Mucosa Gastritis medicine.symptom Tannins Fragola Phytotherapy Signal Transduction |
| Zdroj: | Pharmacological Research. 111:703-712 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/j.phrs.2016.07.028 |
| Popis: | In the present study we chemically profiled tannin-enriched extracts from strawberries and tested their biological properties in a cell model of gastric inflammation. The chemical and biological features of strawberry tannins after in vitro simulated gastric digestion were investigated as well. The anti-inflammatory activities of pure strawberry tannins were assayed to get mechanistic insights. Tannin-enriched extracts from strawberries inhibit IL-8 secretion in TNFα-treated human gastric epithelial cells by dampening the NF-κB signaling. In vitro simulated gastric digestion slightly affected the chemical composition and the biological properties of strawberry tannins. By using pure compounds, we found that casuarictin may act as a pure NF-κB inhibitor while agrimoniin inhibits IL-8 secretion also acting on other biological targets; in our system procyanidin B1 prevents the TNFα-induced effects without interfering with the NF-κB pathway. We conclude that strawberry tannins, even after in vitro simulated gastric digestion, exert anti-inflammatory activities at nutritionally relevant concentrations. |
| Databáze: | OpenAIRE |
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