Complex congenital malformations and the impact of the plasminogen activator system and beta-hCG in amniotic fluid
| Autor: | Fred C.G.J. Sweep, Anna C. Verkleij-Hagoort, Eric A.P. Steegers, Anneke Geurts-Moespot, Régine P.M. Steegers-Theunissen, Nicolette T.C. Ursem, Wim C. J. Hop |
|---|---|
| Přispěvatelé: | Obstetrics & Gynecology, Epidemiology |
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Amniotic fluid Angiogenesis Aetiology screening and detection [ONCOL 5] Congenital Abnormalities Neovascularization Pathogenesis Pregnancy Translational research [ONCOL 3] Internal medicine Plasminogen Activator Inhibitor 1 Plasminogen Activator Inhibitor 2 medicine Humans Chorionic Gonadotropin beta Subunit Human T-plasminogen activator business.industry Endocrinology and reproduction [UMCN 5.2] Hormonal regulation [IGMD 6] Obstetrics and Gynecology Amniotic Fluid Urokinase-Type Plasminogen Activator Endocrinology Reproductive Medicine Case-Control Studies Tissue Plasminogen Activator Amniocentesis Gestation Female Neural crest cell migration medicine.symptom business Plasminogen activator |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology, 135, 1, pp. 47-52 European Journal of Obstetrics & Gynecology and Reproductive Biology, 135, 47-52 European Journal of Obstetrics, Gynecology and Reproductive Biology, 135(1), 47-52. Elsevier Ireland Ltd |
| ISSN: | 1872-7654 0028-2243 0301-2115 |
| Popis: | Contains fulltext : 53585.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The plasminogen activator system and beta-hCG may affect neural crest cells and angiogenesis, and thereby embryogenesis. Therefore, we investigated these parameters in amniotic fluids of pregnancies with a complex congenital malformation. STUDY DESIGN: In a case-control study amniotic fluid samples were collected from 62 pregnancies with a complex congenital malformation and from 110 healthy control pregnancies at an obstetric department of a large university hospital in the Netherlands. We determined concentrations of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitors (PAI-1, PAI-2), tPA approximately PAI-1 and uPA approximately PAI-1 complexes, and beta-hCG with enzyme-linked immunosorbent assays. Mann-Whitney U-tests and analysis of covariance, adjusting for gestational and maternal age, were performed for data comparisons. RESULTS: Compared with controls, cases demonstrated significantly lower adjusted geometric mean levels of uPA (24%), tPA (> or =19%) and tPA approximately PAI-1 (35%). Cases showed significantly higher adjusted mean levels of beta-hCG (> or =48%) and PAI-2 (10 ng/mL) than controls. Mean PAI-1 and uPA approximately PAI-1 levels were comparable between both groups. CONCLUSIONS: Disturbances in the plasminogen activator system and beta-hCG levels are suggested to be involved in the pathogenesis of complex congenital malformations by affecting neural crest cell migration and angiogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect