Antifungal activity of substituted aurones
| Autor: | Zachary E. Taylor, Mary B. Farone, Caleb L. Sutton, Scott T. Handy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antifungal Antifungal Agents medicine.drug_class 030106 microbiology Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Microbiology Candida tropicalis Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Drug Discovery Aurone Ic50 values medicine In patient Candida albicans Molecular Biology Benzofurans Candida Candida glabrata biology Chemistry Organic Chemistry biology.organism_classification 030104 developmental biology Biofilms Candida spp Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 27:901-903 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2017.01.012 |
| Popis: | Novel antifungals are in high demand as there is a growing resistance to antifungals currently in use. In particular, opportunistic fungal infections caused by Candida spp. are on the rise with infections by this genus accounting for the most severe fungal infections following chemotherapy, implantation procedures, and in patients with HIV/AIDS. A series of simple aurone analogs were synthesized and screened for antifungal activity versus Candida spp. Several compounds displayed activity at 100 μM, with two having IC50 values below 20 μM for three species of Candida. One of the compounds tested here also exhibits anti-biofilm activity for mid-maturation growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect